With her talk show coming to a close after 25 years, Oprah has said she's set to turn her focus to the Oprah Winfrey Network (OWN), but what if the influential media mogul ventured into the world of politics? As one of the richest Americans in the nation, Ms. Winfrey surely knows how to run a business with a string of ventures in film, radio, publishing, and, of course, television.